Publications

The Nathan Shock Center investigators have produced significant research contributions in aging biology over the past two years. Below are key publications organized by year, highlighting our center's impact on the field of aging research.

2025 Publications

• Gilbert MB, Glastad KM, Fioriti M, Sorek M, Scarpa T, Purnell FS, Xu D, Pino LK, Korotkov A, Biashad A, Baeza J, Lauman R, Filippova A, Kacsoh BZ, Bonasio R, Mathis MW, Garcia BA, Seluanov A, Gorbunova V, Berger SL. Neuropeptides specify and reprogram division of labor in the leafcutter ant Atta cephalotes. Cell. 2025.
• Robbins P, Zhang L, Elsallabi O, Soto-Palma C, Bartz J, Salekeen R, Nunes A, Xu W, Lee K, Hughes B, Zhang B, Mohamed A, McGowan S, Angelini L, O’Kelly R, Biashad SA, Hillpot E, Morandini F, Seluanov A, Gorbunova V, Dong X, Niedernhofer L. Fucoidans are senotherapeutics that enhance SIRT6-dependent DNA repair. Res Sq [Preprint]. 2025.
• Meadow ME, Broas S, Hoare M, Ahmed M, Alimohammadi F, Welle KA, Swovick K, Hryhorenko JR, Jain A, Martinez JC, Seluanov A, Gorbunova V, Buchwalter A, Ghaemmaghami S. Proteome Birthdating: A Single-Sample Approach for Measuring Global Turnover Dynamics and “Protein Age”. Bio Protoc. 2025.
• Athar F, Zheng Z, Riquier S, Zacher M, Lu JY, Zhao Y, Volobaev V, Alcock D, Galazyuk A, Cooper LN, Schountz T, Wang LF, Teeling EC, Seluanov A, Gorbunova V. Limited cell-autonomous anticancer mechanisms in long-lived bats. Nat Commun. 2025.
• Kroemer G, Maier AB, Cuervo AM, Gladyshev VN, Ferrucci L, Gorbunova V, Kennedy BK, Rando TA, Seluanov A, Sierra F, Verdin E, López-Otín C. From geroscience to precision geromedicine: Understanding and managing aging. Cell. 2025.
• Athar F, Morandini F, Fatima I, Silvestri I, Kim SB, Lee M, Liao X, Sharov A, Botchkarev V, Seluanov A, Gorbunova V. African spiny mice show resistance to DMBA/TPA-induced squamous carcinogenesis with distinct benign tumor profile. Protein Cell. 2025.
• Gorbunova V, Seluanov A. SIRT5 slows skeletal muscle ageing by alleviating inflammation. Nat Metab. 2025.
• Miller KN, Li B, Pierce-Hoffman HR, Patel S, et al. p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells. Nat Commun. 2025.
• Parry RH, Yamada KYH, Hood WR, Zhao Y, Lu JY, Seluanov A, Gorbunova V, Modhiran N, Watterson D, Isaacs A. Henipavirus in Northern Short-Tailed Shrew, Alabama, USA. Emerg Infect Dis. 2025.

2024 Publications

• Gladyshev VN, Anderson B, Barlit H, et al. Disagreement on foundational principles of biological aging. PNAS Nexus. 2024.
• Morandini F, Lu JY, Rechsteiner C, Shadyab AH, Casanova R, Snively BM, Seluanov A, Gorbunova V. Transposable element 5mC methylation state of blood cells predicts age and disease. Nat Aging. 2025.
• Firsanov D, Zacher M, Tian X, Sformo TL, Zhao Y, Tombline G, Lu JY, Zheng Z, Perelli L, Gurreri E, Zhang L, Guo J, Korotkov A, Volobaev V, Biashad SA, Zhang Z, Heid J, Maslov A, Sun S, Wu Z, Gigas J, Hillpot E, Martinez J, Lee M, Williams A, Gilman A, Hamilton N, Haseljic E, Patel A, Straight M, Miller N, Ablaeva J, Tam LM, Couderc C, Hoopman M, Moritz R, Fujii S, Hayman DJ, Liu H, Cai Y, Leung AKL, Simons MJP, Zhang Z, Nelson CB, Abegglen LM, Schiffman JD, Gladyshev VN, Modesti M, Genovese G, Vijg J, Seluanov A, Gorbunova V. DNA repair and anti-cancer mechanisms in the long-lived bowhead whale. bioRxiv [Preprint]. 2024.
• Gilbert MB, Glastad KM, Fioriti M, Sorek M, Gannon T, Xu D, Pino LK, Korotkov A, Biashad A, Baeza J, Lauman R, Filippova A, Kacsoh BZ, Bonasio R, Mathis MW, Garcia BA, Seluanov A, Gorbunova V, Berger SL. Neuropeptides specify and reprogram division of labor in the leafcutter ant Atta cephalotes. bioRxiv [Preprint]. 2024.
• Martinez JC, Morandini F, Fitzgibbons L, Sieczkiewicz N, Bae SJ, Meadow ME, Hillpot E, Cutting J, Paige V, Biashad SA, Simon M, Sedivy J, Seluanov A, Gorbunova V. cGAS deficient mice display premature aging associated with de-repression of LINE1 elements and inflammation. bioRxiv [Preprint]. 2024.
• Takasugi M, Nonaka Y, Takemura K, Yoshida Y, Stein F, Schwarz JJ, Adachi J, Satoh J, Ito S, Tombline G, Biashad SA, Seluanov A, Gorbunova V, Ohtani N. An atlas of the aging mouse proteome reveals the features of age-related post-transcriptional dysregulation. Nat Commun. 2024.
• Martinez JC, Seluanov A, Gorbunova V. LINE1 and its host: one cell’s junk is another cell’s treasure. EMBO J. 2024.
• McGuire J, Taguchi T, Tombline G, Paige V, Janelsins M, Gilmore N, Seluanov A, Gorbunova V. Hyaluronidase inhibitor delphinidin inhibits cancer metastasis. Sci Rep. 2024.
• Li CZ, Haghani A, Yan Q, Lu AT, Zhang J, Fei Z, Ernst J, Yang XW, Gladyshev VN, Robeck TR, Chavez AS, Cook JA, Dunnum JL, Raj K, Seluanov A, Gorbunova V, Horvath S. Epigenetic predictors of species maximum life span and other life-history traits in mammals. Sci Adv. 2024.
• Meadow ME, Broas S, Hoare M, Alimohammadi F, Welle KA, Swovick K, Hryhorenko JR, Martinez JC, Biashad SA, Seluanov A, Gorbunova V, Buchwalter A, Ghaemmaghami S. Proteome Birthdating Reveals Age-Selectivity of Protein Ubiquitination. Mol Cell Proteomics. 2024.
• Sanchez Sanchez G, Emmrich S, Georga M, Papadaki A, Kossida S, Seluanov A, Gorbunova V, Vermijlen D. Invariant γδTCR natural killer-like effector T cells in the naked mole-rat. Nat Commun. 2024.
• Morandini F, Seluanov A, Gorbunova V. Slow and steady lives the longest. Nature Aging, 2024
• Paine PT, Rechsteiner C, Morandini F, …, Seluanov A, Gorbunova V, Ocampo A. Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging. Frontiers in Aging, 2024.